Cheats > Game > Cheat: 380

Defeating Black Tiger (big spider)
Use your strongest weapon. If playing as Chris, use the flamethrower then torch the babies. Alternately, use this easier trick that also saves ammunition. When you fight Black Tiger, there is a smaller spider behind it. Just focus on killing the big one, and forget about the babies and the normal spider by getting out of the room. Every spider will disappear when you return.